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Although RA manifestation includes pain, stiffness, swelling, and functional impairment, it can be difficult to diagnose in the early stages, as its symptoms can closely mimic other diseases.

For this reason, ongoing investigation into the origin of patient variability and ways to enhance RA management/treatment are essential for improving the current level of clinical care provided by rheumatologists.

In this regard, RA is commonly treated using disease-modifying anti-rheumatic drugs (DMARDs) and/or biological therapies (for example, anti-tumor necrosis factor alpha [TNF-a]).

However, a later cross-sectional study among 70 RA patients and 70 controls revealed that HLA-DRB1 *04 was the most frequent allele associated with RA, followed by DRB1 *08, and DRB1 *10.

represented the most frequently used methodologies. Among 340 RA patients from 3 different centers in western SA, hypertension (35.9%) was observed to be the most common comorbidity, followed by diabetes mellitus (30.9%), osteoporosis (25.8%), and dyslipidemia (19.4%).).

Here, we have conducted an electronic literature search via MEDLINE using Pub Med (US National Library of Medicine, 1984 to February 2014), Ovid, and EBSCO databases.

In addition, we performed an electronic search in 3 local journals (for example, Saudi Medical Journal, Annals of Saudi Medicine, and Journal of King Abdulaziz University Medical Science), identifying 2 more articles.

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