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Consider measuring HDL cholesterol in a random sample of subjects from a defined population.The distribution of HDL cholesterol in this population is Normal with some mean (say 60 mg/dl) and standard deviation (say 12 mg/dl).

fluctuations in the HDL cholesterol measurements, or the subject's diet).The cut-point at 40 mg/dl identifies those with a low HDL cholesterol.The second panel focuses on the left tail of the population and hence on those 21 subjects who may be included in the ‘low’ group.It happens because values are observed with random error.By random error we mean a non-systematic variation in the observed values around a true mean (e.g.

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